Table of contents
August 2007 Vol 8 No 8
Research Highlights
Post-translational modification: It doesn't take three | PDF (248 KB)
p596 | doi:10.1038/nrm2232
MicroRNA: Introducing the mirtron | PDF (114 KB)
p597 | doi:10.1038/nrm2225
In brief
In Brief | PDF (86 KB)
p597 | doi:10.1038/nrm2231
Chromatin: A surprise package | PDF (112 KB)
p598 | doi:10.1038/nrm2219
Cell signalling: The power of NetworKIN | PDF (177 KB)
p598 | doi:10.1038/nrm2224
Post-translational modification: UBE1, you're not alone | PDF (144 KB)
p599 | doi:10.1038/nrm2218
Cell division: Protection for cyclists | PDF (192 KB)
p600 | doi:10.1038/nrm2220
Structure Watch
Elongation stopped in its tracks | PDF (75 KB)
p600 | doi:10.1038/nrm2226
Mechanisms of disease: A spate of RAB8 | PDF (163 KB)
p600 | doi:10.1038/nrm2228
In the news
HOTAIR rises: new role for non-coding RNAs | PDF (77 KB)
p601 | doi:10.1038/nrm2229
Reviews
Pathways of clathrin-independent endocytosis
Satyajit Mayor & Richard E. Pagano
p603 | doi:10.1038/nrm2216
Classically, endocytosis involves the formation of clathrin-coated carriers that bud from the plasma membrane by dynamin-dependent mechanisms. Recently, several clathrin-independent endocytic pathways have been identified, which represent the main pathway of entry into cells for a diverse array of cargoes, including receptors, lipids and pathogens.
Filling out the Hippo pathway
Leslie J. Saucedo & Bruce A. Edgar
p613 | doi:10.1038/nrm2221
Intense research has led to the discovery and characterization of a novel signalling network, the Hippo pathway, which is involved in growth control in Drosophila melanogaster. The importance of this pathway is emphasized by its evolutionary conservation and by increasing evidence that its deregulation occurs in human tumours.
Lysosomes: fusion and function
J. Paul Luzio, Paul R. Pryor & Nicholas A. Bright
p622 | doi:10.1038/nrm2217
Far from being a static organelle at the end of the endocytic pathway, the lysosome is capable of dynamically fusing with many organelles as well as the plasma membrane. The lysosome provides hydrolytic enzymes for the degradation of macromolecules, has secretory functions and is important for plasma membrane repair.
Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
Thomas Lecuit & Pierre-François Lenne
p633 | doi:10.1038/nrm2222
Many signalling pathways have been shown to control cell shape and cell surface mechanics. Recent insights from diverse disciplines point to adhesion and cortical tension as regulators of cell shape and provide insights into how cell shape controls tissue geometry.
Analysis of protein complexes using mass spectrometry
Anne-Claude Gingras, Matthias Gstaiger, Brian Raught & Ruedi Aebersold
p645 | doi:10.1038/nrm2208
The combination of affinity purification and mass spectrometry (AP–MS) has recently been applied to the detailed characterization of protein complexes and large protein-interaction networks. Emerging AP–MS approaches promise a better understanding of protein-complex stoichiometry, structural organization and the dynamics of protein-complex composition.
The ins and outs of the plant cell cycle
Lieven De Veylder, Tom Beeckman & Dirk Inzé
p655 | doi:10.1038/nrm2227
Considerable progress has been made in understanding the mechanisms that control cell division in plants. However, little is known about how the cell cycle responds to environmental and developmental stimuli and how the cell cycle is turned on and off.
Perspective
Opinion
What's taking so long? S-phase entry from quiescence versus proliferation
Hilary A. Coller
p667 | doi:10.1038/nrm2223
When quiescent cells re-enter the cell cycle, why do they require several extra hours in the G1 phase before they replicate their DNA? One hypothesis is that the proteins that are required for the formation of pre-replicative complexes are removed from chromatin.
Erratum: Mechanisms of specificity in protein phosphorylation
Jeffrey A. Ubersax & James E. Ferrell, Jr
doi:10.1038/nrm2235
