Abstract

There are numerous ways that endocytic cargo molecules may be internalized from the surface of eukaryotic cells. In addition to the classical clathrin-dependent mechanism of endocytosis, several pathways that do not use a clathrin coat are emerging. These pathways transport a diverse array of cargoes and are sometimes hijacked by bacteria and viruses to gain access to the host cell. Here, we review our current understanding of various clathrin-independent mechanisms of endocytosis and propose a classification scheme to help organize the data in this complex and evolving field.

Author affiliations

1. National Centre for Biological Sciences, UAS-GKVK Campus, Bangalore 560065, India. Email: mayor@ncbs.res.in
2. Mayo Clinic College of Medicine, Departments of Medicine, Biochemistry and Molecular Biology, 200 First Street Southwest, Rochester, Minnesota 55905, USA. Email: pagano.richard@mayo.edu

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