Table of contents
From the editors
p421 | doi:10.1038/nrm2195
Research Highlights
MicroRNA: Translational inhibition interpreted
p422 | doi:10.1038/nrm2194
Cell signalling: New communication skills
p423 | doi:10.1038/nrm2191
Cell division: Tug of war
p423 | doi:10.1038/nrm2192
Development: Go with the flow
p424 | doi:10.1038/nrm2185
Web Watch
How to build a biological model
p424 | doi:10.1038/nrm2186
Mitosis: Where did the membrane go?
p424 | doi:10.1038/nrm2187
Stem cells: Sharing common factors for self-renewal
p425 | doi:10.1038/nrm2181
DNA repair: New players complement the team
p426 | doi:10.1038/nrm2193
Cell cycle: Ubiquitin — a ticket through the checkpoint
p427 | doi:10.1038/nrm2182
In brief
Endocytosis | Nucleoli | Cell division | Epigenetics
p427 | doi:10.1038/nrm2196
Reviews
Inheritance and biogenesis of organelles in the secretory pathway
Martin Lowe & Francis A. Barr
p429 | doi:10.1038/nrm2179
During the cell cycle, organelles such as the endoplasmic reticulum and Golgi apparatus must be replicated and partitioned into the daughter cells. Different mechanisms have evolved in yeasts, protozoa and metazoans to solve this problem.
Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst & Boudewijn M.T. Burgering
p440 | doi:10.1038/nrm2190
Common regulatory enzymes affect the function of the class O of forkhead box transcription factors (FoxOs) and p53 in an opposite manner. Recent findings indicate that this shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.
Centrosome biogenesis and function: centrosomics brings new understanding
Mónica Bettencourt-Dias & David M. Glover
p451 | doi:10.1038/nrm2180
Recent large-scale functional genomics and proteomics analyses have revealed novel molecules that are involved in regulating centrosome function and biogenesis. Other studies indicate that certain molecules that inhibit the re-replication of DNA might also inhibit centriole reduplication, thereby linking chromosome and centrosome cycles.
Molecular regulation of angiogenesis and lymphangiogenesis
Ralf H. Adams & Kari Alitalo
p464 | doi:10.1038/nrm2183
The growth of the blood and lymphatic systems provides an excellent example for the tight coordination of diverse cellular processes during tissue morphogenesis. Elucidation of the molecular players and their roles in the development of endothelial networks will also provide insights into human disease.
RNA-binding proteins: modular design for efficient function
Bradley M. Lunde, Claire Moore & Gabriele Varani
p479 | doi:10.1038/nrm2178
Many RNA-binding proteins have a modular structure and are composed of multiple repeats of a few small RNA-binding domains. By arranging the domains in various ways, these proteins can carry out their diverse biological roles in an RNA-specific manner.
Unravelling developmental dynamics: transient intervention and live imaging in plants
G. Venugopala Reddy, Sean P. Gordon & Elliot M. Meyerowitz
p491 | doi:10.1038/nrm2188
Understanding the mechanisms of plant development requires the ability to monitor the spatial and temporal control of gene and protein activity as well as cell behaviours in real time in vivo. The dynamic properties of plant processes can now be captured through the simultaneous use of live imaging and transient perturbation technologies.
Perspective
Article series: Stem cells
Opinion
Embryonic stem-cell culture as a tool for developmental cell biology
Shin-Ichi Nishikawa, Lars Martin Jakt & Takumi Era
p502 | doi:10.1038/nrm2189
In vitro embryonic stem (ES)-cell studies present a unique set of tools to understand embryonic development; however, these studies face many challenges. What are the current and future strategies for the exploitation of ES cells in developmental cell biology?
Correspondence
Correspondence: The Turing mechanism in vertebrate limb patterning
Stuart A. Newman
| doi:10.1038/nrm1830-c1
