Abstract

Many RNA-binding proteins have modular structures and are composed of multiple repeats of just a few basic domains that are arranged in various ways to satisfy their diverse functional requirements. Recent studies have investigated how different modules cooperate in regulating the RNA-binding specificity and the biological activity of these proteins. They have also investigated how multiple modules cooperate with enzymatic domains to regulate the catalytic activity of enzymes that act on RNA. These studies have shown how, for many RNA-binding proteins, multiple modules define the fundamental structural unit that is responsible for biological function.

Author affiliations

1. Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
2. Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
3. Department of Biomolecular Structure and Design, University of Washington, Seattle, Washington 98195, USA.
4. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA.

Correspondence to: Gabriele Varani^1,2 Email: varani@chem.washington.edu

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