Review
Nature Reviews Molecular Cell Biology 8, 345-354 (May 2007) | doi:10.1038/nrm2164
Article series: Stem cells
Stem-cell niches: nursery rhymes across kingdoms
Ben Scheres1 About the author
Abstract
Despite the large evolutionary distance between the plant and animal kingdoms, stem cells in both reside in specialized cellular contexts called stem-cell niches. Although stem-cell-specification factors have been recruited from plant-specific gene families, maintenance factors that repress stem-cell differentiation are conserved between plants and animals. Recent evidence indicates that stem cells in multicellular organisms can be specified by kingdom-specific patterning mechanisms that connect to a related core of epigenetic stem-cell factors.
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Author affiliations
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Molecular Genetics Group, Department of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.
Email: b.scheres@bio.uu.nl
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