Review
Nature Reviews Molecular Cell Biology 8, 379-393 (May 2007) | doi:10.1038/nrm2163
The spindle-assembly checkpoint in space and time
Andrea Musacchio1 & Edward D. Salmon2 About the authors
Abstract
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores — structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
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Author affiliations
- Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan; and Research Unit of the Italian Institute of Technology (IIT) Foundation at the IFOM-IEO Campus, Via Adamello 16, I-20135 Milan, Italy.
- Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA.
Correspondence to: Andrea Musacchio1 Email: andrea.musacchio@ifom-ieo-campus.it
Correspondence to: Edward D. Salmon2 Email: tsalmon@email.unc.edu
Published online 11 April 2007
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