Table of contents
From the editors
p265 | doi:10.1038/nrm2159
Research Highlights
Post-translational modification: Chain reaction
p267 | doi:10.1038/nrm2148
MicroRNA: Mother's contribution
p268 | doi:10.1038/nrm2152
Membrane trafficking: Dampening down destruction in dendritic cells
p268 | doi:10.1038/nrm2158
Chromatin: Shaping the landscape
p269 | doi:10.1038/nrm2149
Chromatin: We are family
p270 | doi:10.1038/nrm2150
DNA repair: Tolerance is not a virtue
p271 | doi:10.1038/nrm2155
Mechanisms of disease: Inhibiting 
-secretase activity
p272 | doi:10.1038/nrm2156
Microscopy: Eukaryotic cell, now showing in 3D
p272 | doi:10.1038/nrm2157
Stem cells: Epidermis — a population in question
p273 | doi:10.1038/nrm2151
Reviews
Article series: Mechanisms of disease
p53 in health and disease
Karen H. Vousden & David P. Lane
p275 | doi:10.1038/nrm2147
p53 is best known as a tumour suppressor, although recent studies have challenged the view that this is its only role. Instead, p53 has important functions in organismal development, and might contribute to a number of diseases other than cancer.
Histone acetyltransferase complexes: one size doesn't fit all
Kenneth K. Lee & Jerry L. Workman
p284 | doi:10.1038/nrm2145
Histone acetyltransferases (HATs) are highly diverse multiprotein complexes that carry out diverse functions, ranging from repairing regions of DNA damage to maintaining overall genomic integrity. HATs are regulated by associated factors and by the dynamic interplay with existing histone modifications.
Netrins: beyond the brain
Vincenzo Cirulli & Mayra Yebra
p296 | doi:10.1038/nrm2142
Although netrins were identified as migrational cues in the developing central nervous system (CNS), recent work has highlighted previously unrecognized functions of netrins outside the CNS. Netrins regulate diverse processes, such as cell adhesion, motility, proliferation, differentiation and, ultimately, cell survival.
Regulation of histone methylation by demethylimination and demethylation
Robert J. Klose & Yi Zhang
p307 | doi:10.1038/nrm2143
Methylation of histone residues is important for the regulation of gene transcription, epigenetic inheritance and cell fate. Histone methylation was long considered a stable modification, but the recent identification of a histone deiminase and histone demethylases has shown that histone methylation can be dynamically regulated.
Analysis
The folding and evolution of multidomain proteins
Jung-Hoon Han, Sarah Batey, Adrian A. Nickson, Sarah A. Teichmann & Jane Clarke
p319 | doi:10.1038/nrm2144
Although most proteins contain multiple domains, nearly all folding studies so far have been of single domains in isolation. Here we consider the importance of interdomain cooperativity in protein folding and propose evolutionary mechanisms that prevent misfolding in multidomain proteins.
Perspective
Opinion
Helping Wingless take flight: how WNT proteins are secreted
George Hausmann, Carla Bänziger & Konrad Basler
p331 | doi:10.1038/nrm2141
Recent studies have identified some of the factors that are involved in WNT secretion and have brought the focus of WNT research to the issue of how WNT proteins are secreted. What are the possible mechanisms that underlie this process?
