Perspectives
Nature Reviews Molecular Cell Biology 8, 331-336 (April 2007) | doi:10.1038/nrm2141
Opinion: Helping Wingless take flight: how WNT proteins are secreted
George Hausmann1, Carla Bänziger1 & Konrad Basler1 About the authors
Abstract
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.
Author affiliations
- George Hausmann, Carla Bänziger and Konrad Basler are at the Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
Correspondence to: Konrad Basler1 Email: basler@molbio.unizh.ch
Published online 7 March 2007
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