Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Review
Nature Reviews Molecular Cell Biology 8, 221–233 (1 March 2007) | doi:10.1038/nrm2125
Matrix metalloproteinases and the regulation of tissue remodelling
&
Abstract
Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
