Review
Nature Reviews Molecular Cell Biology 8, 209-220 (March 2007) | doi:10.1038/nrm2124
Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
A. Gregory Matera1, Rebecca M. Terns2 & Michael P. Terns2 About the authors
Abstract
Recent advances have fuelled rapid growth in our appreciation of the tremendous number, diversity and biological importance of non-coding (nc)RNAs. Because ncRNAs typically function as ribonucleoprotein (RNP) complexes and not as naked RNAs, understanding their biogenesis is crucial to comprehending their regulation and function. The small nuclear and small nucleolar RNPs are two well studied classes of ncRNPs with elaborate assembly and trafficking pathways that provide paradigms for understanding the biogenesis of other ncRNPs.
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Author affiliations
-
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106-4955, USA.
Email: a.matera@case.edu -
Departments of Biochemistry & Molecular Biology, and Genetics, University of Georgia, Athens, Georgia 30602, USA.
Email: rterns@bmb.uga.edu; Email: mterns@bmb.uga.edu
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