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Nature Reviews Molecular Cell Biology 8, 161–167 (1 February 2007) | doi:10.1038/nrm2100
Microtubule-organizing centres: a re-evaluation
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Abstract
The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires γ-tubulin. Here we discuss recent evidence indicating that γ-tubulin-dependent formation of new microtubules is not restricted to conventional microtubule-organizing centres. These findings suggest that the spatio-temporal control of microtubule nucleation is more complex than previously thought, leading us to a re-evaluation of the concept of the microtubule-organizing center.
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