Cell migration: Follow the leader! | PDF (179 KB)

p941 | doi:10.1038/nrm2302

Development: Purine to my eyes | PDF (122 KB)

p942 | doi:10.1038/nrm2300

DNA-damage response: Chewing at the ends | PDF (174 KB)

p942 | doi:10.1038/nrm2301

Cell migration: Invasion of the pseudopods | PDF (215 KB)

p943 | doi:10.1038/nrm2296

Cell cycle: Passengers travel together | PDF (303 KB)

p944 | doi:10.1038/nrm2294

Tumorigenesis: Taking an alternative route | PDF (505 KB)

p945 | doi:10.1038/nrm2307

Development: Dancing the polonaise | PDF (152 KB)

p946 | doi:10.1038/nrm2305

Concepts in sumoylation: a decade on

Ruth Geiss-Friedlander & Frauke Melchior

p947 | doi:10.1038/nrm2293

SUMO (small ubiquitin-related modifier) is a reversible post-translational protein modifier that causes molecular alterations in sumoylated target proteins, leading to changes in localization, activity and stability. In the past 10 years, mechanisms and principles that govern sumoylation have been elucidated.

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Synergistic control of cell adhesion by integrins and syndecans

Mark R. Morgan, Martin J. Humphries & Mark D. Bass

p957 | doi:10.1038/nrm2289

Although integrins and syndecans are crucial for adhesion and multicellular existence, their relative and functional contributions to cell–extracellular matrix interactions remain obscure. However, evidence suggests that synergistic signalling between these adhesion-receptor families is central to their adhesive function, to regulation of cell behaviour and to avoidance of disease.

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TGF–SMAD signal transduction: molecular specificity and functional flexibility

Bernhard Schmierer & Caroline S. Hill

p970 | doi:10.1038/nrm2297

Transforming growth factor- (TGF)-induced signalling converges on a limited number of SMAD complexes. These complexes effect a plethora of specific and functional responses in both embryos and adult organisms. How are these complex cellular responses elicited?

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Multivalent engagement of chromatin modifications by linked binding modules

Alexander J. Ruthenburg, Haitao Li, Dinshaw J. Patel & C. David Allis

p983 | doi:10.1038/nrm2298

Histone post-translational modifications have crucial roles in genome management, in part by recruiting specific factors that alter the structural properties of chromatin. These so-called effector complexes often comprise multiple histone-binding modules that may act in concert to regulate chromatin structure and DNA-related activities.

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Predicting protein function from sequence and structure

David Lee, Oliver Redfern & Christine Orengo

p995 | doi:10.1038/nrm2281

Given the amino-acid sequence or 3D structure of a protein, how much can we predict about its function using just a desktop computer? The recent explosive growth in the volume of sequence data and advancement in computational methods has put more tools at the biologist's disposal than ever before.

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

Rosa Bernardi & Pier Paolo Pandolfi

p1006 | doi:10.1038/nrm2277

The PML tumour suppressor is necessary for the formation of dynamic nuclear organelles called promyelocytic leukaemia nuclear bodies (PML-NBs). Recent data suggest that different PML-NBs may regulate specific cellular functions according to their protein composition, their position in the nucleus and their mobility.

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