Table of contents
From the editors
p847 | doi:10.1038/nrm2290
Research Highlights
Membrane trafficking: Knowing your ESCRT | PDF (218 KB)
p849 | doi:10.1038/nrm2288
Small RNAs: Piwi silences the crowd | PDF (161 KB)
p850 | doi:10.1038/nrm2282
Cell division: Fractal cycling | PDF (576 KB)
p850 | doi:10.1038/nrm2284
Stem cells: Exception to the rule? | PDF (247 KB)
p851 | doi:10.1038/nrm2279
Cell polarity: Persistently on PAR | PDF (163 KB)
p852 | doi:10.1038/nrm2283
Structure Watch
AMPK goes interactive | PDF (95 KB)
p852 | doi:10.1038/nrm2286
Gene expression: Basal crosstalk | PDF (270 KB)
p852 | doi:10.1038/nrm2291
In brief
Mechanotransduction | DNA repair | Nuclear transport | PDF (90 KB)
p853 | doi:10.1038/nrm2292
Mechanisms of disease: Kinases out of control — brake line cut! | PDF (296 KB)
p854 | doi:10.1038/nrm2280
Proliferation: Size is everything | PDF (210 KB)
p854 | doi:10.1038/nrm2285
Reviews
Extracellular control of TGF
signalling in vascular development and disease
Peter ten Dijke & Helen M. Arthur
p857 | doi:10.1038/nrm2262
Recent studies of human genetic syndromes and transgenic mouse models with vascular pathology have exposed a crucial function of extracellular control in the regulation of TGF
bioavailability in the vascular system. This Review discusses such regulation and the implications of defects in this process with regards to human health.
Functions and dysfunctions of mitochondrial dynamics
Scott A. Detmer & David C. Chan
p870 | doi:10.1038/nrm2275
Mitochondria constantly fuse and divide, are actively transported to specific subcellular localizations and have dynamic structures. Mitochondrial dynamics is important for the functional state of mitochondria, and defects can manifest in mammalian development, apoptosis and neurodegenerative disease.
Article series: Mechanisms of disease
When cilia go bad: cilia defects and ciliopathies
Manfred Fliegauf, Thomas Benzing & Heymut Omran
p880 | doi:10.1038/nrm2278
Cilia — tiny hair-like organelles attached to the cell surface — are located on most polarized cells and have been adapted as versatile tools for various cellular functions. Several molecular mechanisms affecting the structure and function of distinct cilia types are associated with cilia-related disorders.
Finishing mitosis, one step at a time
Matt Sullivan & David O. Morgan
p894 | doi:10.1038/nrm2276
The successful completion of mitosis requires that late mitotic events occur in a strict sequence. This is regulated, at least in part, by the order in which different cyclin-dependent kinase substrates are dephosphorylated and in which anaphase-promoting complex substrates are degraded.
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
Kun Ping Lu & Xiao Zhen Zhou
p904 | doi:10.1038/nrm2261
Phosphorylation is a universal regulatory mechanism that induces changes in protein conformation. However, certain phosphorylated motifs can be further regulated by the prolyl isomerase PIN1, which is of increasing importance in aspects of physiology and disease.
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Michael Forgac
p917 | doi:10.1038/nrm2272
The vacuolar ATPases are proton pumps that have a central role in maintaining the pH of intracellular compartments and in proton transport across the plasma membrane. Their activity is controlled at many different levels and, increasingly, their dysregulation is being linked to specific diseases.
Perspective
Timeline
Autophagy: from phenomenology to molecular understanding in less than a decade
Daniel J. Klionsky
p931 | doi:10.1038/nrm2245
Ten years ago, few people had heard of the term autophagy (literally 'self-eating'). But less than a decade later, research in the field has exploded, and recent studies have uncovered an integral role for autophagy in various human diseases.
