Nature Reviews Molecular Cell Biology 8, 798-812 (October 2007) | doi:10.1038/nrm2257

Chromosomal passengers: conducting cell division

Sandrine Ruchaud1, Mar Carmena1 & William C. Earnshaw1  About the authors


Mitosis and meiosis are remarkable processes during which cells undergo profound changes in their structure and physiology. These events are orchestrated with a precision that is worthy of a classical symphony, with different activities being switched on and off at precise times and locations throughout the cell. One essential 'conductor' of this symphony is the chromosomal passenger complex (CPC), which comprises Aurora-B protein kinase, the inner centromere protein INCENP, survivin and borealin (also known as Dasra-B). Studies of the CPC are providing insights into its functions, which range from chromosome–microtubule interactions to sister chromatid cohesion to cytokinesis, and constitute one of the most dynamic areas of ongoing mitosis and meiosis research.

Author affiliations

  1. Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.

Correspondence to: William C. Earnshaw1 Email:


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Borealin shines light on spindle dynamics

Nature Cell Biology News and Views (01 Aug 2004)

INCENP at the kinase crossroads

Nature Cell Biology News and Views (01 Feb 2006)

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