Review
Nature Reviews Molecular Cell Biology 8, 49-62 (January 2007) | doi:10.1038/nrm2083
Integrating cell-signalling pathways with NF-
B and IKK function
Neil D. Perkins1 About the author
Abstract
Nuclear factor (NF)-
B and inhibitor of NF-B kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-B or IKK function contributes to many human diseases, including cancer. However, the NF-B and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-B and IKK activation and, ultimately, cell fate.
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Author affiliations
- College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK. Email: n.d.perkins@dundee.ac.uk
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