Abstract
The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep–wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.
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Acknowledgements
We thank S. Martin, E. Epperson, P. Franken and R. Greene for valuable input on hibernation and sleep. This work is supported by an NIH grant, an NIH Director's Pioneer Award, unrestricted funds from an anonymous donor (S.L.M.), and a Helen Hay Whitney Foundation Postdoctoral Fellowship (B.P.T.).
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Tu, B., McKnight, S. Metabolic cycles as an underlying basis of biological oscillations. Nat Rev Mol Cell Biol 7, 696–701 (2006). https://doi.org/10.1038/nrm1980
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DOI: https://doi.org/10.1038/nrm1980
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