Review
Nature Reviews Molecular Cell Biology 7, 657-666 (September 2006) | doi:10.1038/nrm1986
Genome-wide patterns of histone modifications in yeast
Catherine B. Millar1 & Michael Grunstein1 About the authors
Abstract
Post-translational histone modifications and histone variants generate complexity in chromatin to enable the many functions of the chromosome. Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome. These experiments describe how combinations of modified and unmodified states relate to each other and particularly to chromosomal landmarks that include heterochromatin, subtelomeric chromatin, centromeres, origins of replication, promoters and coding regions. Such patterns might be important for the regulation of heterochromatin-mediated silencing, chromosome segregation, DNA replication and gene expression.
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Author affiliations
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Department of Biological Chemistry, Geffen School of Medicine and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.
Email: cmillar@mednet.ucla.edu
Email: mg@mbi.ucla.edu
Published online 16 August 2006
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