Perspectives

Nature Reviews Molecular Cell Biology 7, 696-701 (September 2006) | doi:10.1038/nrm1980



There is a Correspondence by Lloyd and by Murray and an Author Reply associated with this Article.

OpinionMetabolic cycles as an underlying basis of biological oscillations

View Correspondence (December 2006; December 2006) and related Reply (December 2006) associated with this article.

Benjamin P. Tu1 & Steven L. McKnight1  About the authors

Top

The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep–wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.

Author affiliations

  1. Benjamin P. Tu and Steven L. McKnight are at the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA.
    Email: bentu@biochem.swmed.edu
    Email: smckni@biochem.swmed.edu

Published online 5 July 2006

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Metabolism Tick, tock, a β-cell clock

Nature News and Views (29 Jul 2010)

Rhythm is not enough

Nature Genetics News and Views (01 Oct 2007)

See all 6 matches for News And Views

RESEARCH

The ultradian clock: not to be confused with the cell cycle

Nature Reviews Molecular Cell Biology Correspondence (01 Dec 2006)

See all 13 matches for Research