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Nature Reviews Molecular Cell Biology 7, 617–622 (1 August 2006) | doi:10.1038/nrm1941

Proteome chips for whole-organism assays

Li A. Kung & Michael Snyder

Over the past 5 years, protein-chip technology has emerged as a useful tool for the study of many kinds of protein interactions and biochemical activities. The construction of Saccharomyces cerevisiae whole-proteome arrays has enabled further studies of such interactions in a proteome-wide context. Here, we explore some of the recent advances that have been made at the '-omic' level using protein microarrays.