Table of contents
July 2006 Vol 7 No 7
Also this month:
- Article series: Mechanisms of disease
- Poster: Reading protein and phospholipid modifications with interaction domains
From The Editors
p463 | doi:10.1038/nrm1970
Research Highlights
Membrane dynamics: Maturing is part of life
p465 | doi:10.1038/nrm1972
Chromatin: Fine-tuning tools
p466 | doi:10.1038/nrm1967
Cell adhesion: Hang on to survive
p466 | doi:10.1038/nrm1974
In the news
More Small RNAs
p466 | doi:10.1038/nrm1978
Structure Watch
Unmake a mark | Cage control
p467 | doi:10.1038/nrm1975
Cell migration: The flight of the haemocyte
p468 | doi:10.1038/nrm1965
Development: FGF8 — you're making my heart!
p468 | doi:10.1038/nrm1969
Gene expression: Pointing the finger
p469 | doi:10.1038/nrm1966
Cell signalling: Going global
p470 | doi:10.1038/nrm1968
MicroRNA: Microprocessor measures up
p470 | doi:10.1038/nrm1973
In brief
Microbiology | Phagocytosis | Tumour suppressor | Ageing
p471 | doi:10.1038/nrm1971
Tumorigenesis: A new pathway for CYLD
p471 | doi:10.1038/nrm1977
Reviews
Reading protein modifications with interaction domains
Bruce T. Seet, Ivan Dikic, Ming-Ming Zhou & Tony Pawson
p473 | doi:10.1038/nrm1960
Proteins are controlled by post-translational modifications that can be recognized by specific protein-interaction domains. These domains read the state of the proteome and therefore couple post-translational modifications to cellular organization. But how do modification-dependent interactions synergize to regulate cell behaviour?
The biogenesis and regulation of telomerase holoenzymes
Kathleen Collins
p484 | doi:10.1038/nrm1961
The extensive biochemical and molecular characterization of telomerase holoenzymes has provided new insights into the regulation and function of this specialized polymerase in different model organisms. New approaches are now required to investigate telomerases in physiological context.
Article series: Mechanisms of disease
: Mechanisms of pathogen entry through the endosomal compartments
Jean Gruenberg & F. Gisou van der Goot
p495 | doi:10.1038/nrm1959
Recent advances have shed light on the interactions that occur between pathogens and endocytic pathway components. With the aim of generating suitable replication niches, microorganisms use existing cellular pathways and have developed selective and manipulative behaviour to avoid lysosome-mediated killing.
EGF–ERBB signalling: towards the systems level
Ami Citri & Yosef Yarden
p505 | doi:10.1038/nrm1962
The ERBB network is one of the most studied areas in signal transduction, and it exemplifies the pathogenic power of aberrant signalling. Systems-level modelling and an understanding of the network's circuitry, robustness and controls will enable the development of novel cancer therapies.
Poly(ADP-ribose): novel functions for an old molecule
Valérie Schreiber, Françoise Dantzer, Jean-Christophe Ame & Gilbert de Murcia
p517 | doi:10.1038/nrm1963
The transfer of poly(ADP-ribose) (PAR) to proteins is mediated by the growing family of PAR polymerases. This post-translational modification regulates many important cellular processes, including maintenance of genome integrity, gene expression and cell division, and is emerging as an important epigenetic mark.
RNA-quality control by the exosome
Jonathan Houseley, John LaCava & David Tollervey
p529 | doi:10.1038/nrm1964
The exosome complex of 3'
5' exoribonucleases degrades many types of RNA in the nucleus and the cytoplasm that are targeted by the cell's RNA-surveillance machinery. It is also responsible for the precise trimming of the 3' ends of nuclear RNA precursors during RNA maturation.
Perspective
Opinion
Chromatin in pluripotent embryonic stem cells and differentiation
Eran Meshorer & Tom Misteli
p540 | doi:10.1038/nrm1938
What makes a stem cell is still poorly understood. Recent studies have uncovered that chromatin might hold some of the keys to how embryonic stem cells maintain their pluripotency, their ability to self-renew and induce lineage specification.
