Review
Nature Reviews Molecular Cell Biology 7, 415-425 (June 2006) | doi:10.1038/nrm1942
Early nonsense: mRNA decay solves a translational problem
Nadia Amrani1, Matthew S. Sachs2,3 & Allan Jacobson1 About the authors
Abstract
Gene expression is highly accurate and rarely generates defective proteins. Several mechanisms ensure this fidelity, including specialized surveillance pathways that rid the cell of mRNAs that are incompletely processed or that lack complete open reading frames. One such mechanism, nonsense-mediated mRNA decay, is triggered when ribosomes encounter a premature translation-termination — or nonsense — codon. New evidence indicates that the specialized factors that are recruited for this process not only promote rapid mRNA degradation, but are also required to resolvea poorly dissociable termination complex.
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Author affiliations
- Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655-0122, USA.
- Department of Environmental and Biomolecular Systems, Oregon Health and Science University, Beaverton, Oregon 97006, USA.
- Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97201, USA.
Correspondence to: Allan Jacobson1 Email: allan.jacobson@umassmed.edu
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