Review

Nature Reviews Molecular Cell Biology 7, 404-414 (June 2006) | doi:10.1038/nrm1940

Harnessing actin dynamics for clathrin-mediated endocytosis

Marko Kaksonen1, Christopher P. Toret1 & David G. Drubin1  About the authors

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Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells. A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane — namely endocytosis — has recently been established. Live-cell imaging studies are shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.

Author affiliations

  1. Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202, USA.

Correspondence to: David G. Drubin1 Email: drubin@socrates.berkeley.edu

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