Review
Nature Reviews Molecular Cell Biology 7, 265-275 (April 2006) | doi:10.1038/nrm1890
Local force and geometry sensing regulate cell functions
Viola Vogel1 & Michael Sheetz2 About the authors
Abstract
The shapes of eukaryotic cells and ultimately the organisms that they form are defined by cycles of mechanosensing, mechanotransduction and mechanoresponse. Local sensing of force or geometry is transduced into biochemical signals that result in cell responses even for complex mechanical parameters such as substrate rigidity and cell-level form. These responses regulate cell growth, differentiation, shape changes and cell death. Recent tissue scaffolds that have been engineered at the micro- and nanoscale level now enable better dissection of the mechanosensing, transduction and response mechanisms.
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Author affiliations
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Laboratory for Biologically Oriented Materials, Department of Materials, Swiss Federal Institute of Technology (ETH), Zurich, Wolfgang-Pauli-Strasse 10, ETH Hönggerberg, HCI F443, CH-8093 Zürich, Switzerland.
Email: viola.vogel@mat.ethz.ch -
Department of Biological Sciences, P.O. Box 2408, Columbia University, Sherman Fairchild Center, Room 713, 1212 Amsterdam Avenue, New York, New York 10027, USA.
Email: ms2001@columbia.edu
Published online 22 February 2006
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