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Review
Nature Reviews Molecular Cell Biology 7, 165–176 (1 March 2006) | doi:10.1038/nrm1838
Cell-signalling dynamics in time and space
Abstract
Spatial and temporal dynamics of signalling networks control the specificity of cellular responses to receptor stimulation. Computational models now provide insights into the mechanisms that are responsible for signal amplification, as well as the timing, amplitude, duration and spatial distribution of signalling responses.
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