Perspectives
Nature Reviews Molecular Cell Biology 7, 225-230 (March 2006) | doi:10.1038/nrm1861
Innovation: A visual approach to proteomics
Stephan Nickell1, Christine Kofler1, Andrew P. Leis1 & Wolfgang Baumeister1 About the authors
Abstract
Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4–5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.
Author affiliations
- Stephan Nickell, Christine Kofler, Andrew P. Leis and Wolfgang Baumeister are at the Max Planck Institute for Biochemistry, Department of Structural Biology, Am Klopferspitz 18, D-82152 Martinsried, Germany.
Correspondence to: Wolfgang Baumeister1 Email: baumeist@biochem.mpg.de
Published online 15 February 2006
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