Review
Nature Reviews Molecular Cell Biology 7, 165-176 (March 2006) | doi:10.1038/nrm1838
Cell-signalling dynamics in time and space
Boris N. Kholodenko1 About the author
Abstract
The specificity of cellular responses to receptor stimulation is encoded by the spatial and temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to spatial gradients of signalling activities, which guide pivotal intracellular processes and tightly regulate signal propagation across a cell. Computational models provide insights into the complex relationships between the stimuli and the cellular responses, and reveal the mechanisms that are responsible for signal amplification, noise reduction and generation of discontinuous bistable dynamics or oscillations.
- View At a Glance
Author affiliations
-
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA.
Email: Boris.Kholodenko@jefferson.edu
Published online 15 February 2006
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Zero-order switches and developmental thresholdsMolecular Systems Biology News and Views (13 Dec 2005)
Customized signaling with reconfigurable protein scaffoldsNature Biotechnology News and Views (01 May 2008)
RESEARCH
X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolaseNature Structural Biology Article (01 Dec 1997)
The mechanisms of acute ischemic injury in the cell processes of developing white matter astrocytesJournal of Cerebral Blood Flow & Metabolism Original Article
See all 4 matches for Research
