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Review

Nature Reviews Molecular Cell Biology 7, 85–96 (1 February 2006) | doi:10.1038/nrm1837

Critical nodes in signalling pathways: insights into insulin action

Cullen M. Taniguchi , Brice Emanuelli & C. Ronald Kahn

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.