Review
Nature Reviews Molecular Cell Biology 7, 131-142 (February 2006) | doi:10.1038/nrm1835
Complex networks orchestrate epithelial–mesenchymal transitions
Jean Paul Thiery1 & Jonathan P. Sleeman2 About the authors
Abstract
Epithelial–mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
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Author affiliations
- Centre National de la Recherche Scientifique (CNRS) Unité Mixte Recherche (UMR) 144 and Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France. Email: Jean-Paul.Thiery@curie.fr
- Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, 76021 Karlsruhe, Germany. Email: sleeman@itg.fzk.de
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