Review
Nature Reviews Molecular Cell Biology 7, 120-130 (February 2006) | doi:10.1038/nrm1834
MAPKAP kinases — MKs — two's company, three's a crowd
Matthias Gaestel1 About the author
Abstract
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) — MK2, MK3 and MK5 — signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.
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Author affiliations
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Department of Biochemistry, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Email: gaestel.matthias@mh-hannover.de
Published online 18 January 2006
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