Perspectives
Nature Reviews Molecular Cell Biology 7, 143-147 (February 2006) | doi:10.1038/nrm1787
Timeline: The eureka enzyme: the discovery of DNA polymerase
Errol C. Friedberg1 About the author
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Abstract
The identification and partial purification by Arthur Kornberg and his colleagues in 1956 of an enzyme ? DNA polymerase I of Escherichia coli ? that catalysed the stable incorporation of deoxyribonucleotides into DNA in vitro came as a surprise. At the time, most scientists in the field believed that DNA synthesis was too complicated to be accurately reflected outside the living cell.
Author affiliations
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Errol C. Friedberg is at the Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 79503-9072, USA.
Email: errol.friedberg@utsouthwestern.edu
Published online 21 December 2005
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NEWS AND VIEWS
Nobel Prize for Medicine for 1959Nature News and Views (03 Oct 1959)
Obituary Arthur Kornberg (1918?2007)Nature News and Views (06 Dec 2007)
RESEARCH
Synthesis of Deoxyribonucleic Acid in Extracts of Mammalian CellsNature Article (30 Aug 1958)
