Table of contents
From the editors
p75 | doi:10.1038/nrm1871
Research Highlights
Cell adhesion: 
-Catenin: static or dynamic
p77 | doi:10.1038/nrm1852
Cell division: Giving directions
p78 | doi:10.1038/nrm1854
In the news
Meet the neighbours
p78 | doi:10.1038/nrm1865
Sumoylation: The power of SUMO
p78 | doi:10.1038/nrm1867
In brief
Cell cycle | Nuclear envelope | DNA repair | Bacterial invasion
p79 | doi:10.1038/nrm1862
Cell cycle: Signalling crosstalk
p80 | doi:10.1038/nrm1864
Structure Watch
The states of a sensor | A minimal coat cage
p80 | doi:10.1038/nrm1870
In brief
Development | DNA damage | Cell cycle | RNA metabolism
p81 | doi:10.1038/nrm1863
Development: Back talk
p81 | doi:10.1038/nrm1869
Cell signalling: Fill in the Wnt gaps
p82 | doi:10.1038/nrm1853
Protein degradation: Maintaining supplies
p82 | doi:10.1038/nrm1866
DNA repair: Family resemblance
p83 | doi:10.1038/nrm1868
Reviews
Critical nodes in signalling pathways: insights into insulin action
Cullen M. Taniguchi, Brice Emanuelli & C. Ronald Kahn
p85 | doi:10.1038/nrm1837
The concept of 'critical nodes' has been used to define the main junctions in physiologically important, complex signalling networks. Several critical nodes of the insulin network have been identified and shown to have important roles in normal physiology and disease states.
Article series: Developmental Cell Biology
Developmental cell biology: Developmental apoptosis in C. elegans: a complex CEDnario
Guillaume Lettre & Michael O. Hengartner
p97 | doi:10.1038/nrm1836
Apoptosis is integral to the development of the simple nematode, during which it claims >10% of the somatic cells that are generated. Recent insights into the regulation and execution of apoptosis in this organism will increase our understanding of developmental apoptosis in more complex species.
Gating prokaryotic mechanosensitive channels
Eduardo Perozo
p109 | doi:10.1038/nrm1833
Prokaryotic mechanosensitive channels function as molecular switches that transduce bilayer deformations into protein motion. These structural rearrangements generate large non-selective pores that result in fast solute and solvent exchange and function as a prokaryotic 'last line of defence' to sudden osmotic challenges.
MAPKAP kinases — MKs — two's company, three's a crowd
Matthias Gaestel
p120 | doi:10.1038/nrm1834
The MAPK-activated protein kinase (MK) subfamily consists of three structurally related enzymes that function downstream of MAPKs. These kinases are involved in the regulation of actin architecture, cell migration, development, cell-cycle progression and chromatin remodelling as well as mRNA stability and translation.
Complex networks orchestrate epithelial–mesenchymal transitions
Jean Paul Thiery & Jonathan P. Sleeman
p131 | doi:10.1038/nrm1835
Epithelial–mesenchymal transition (EMT) is an essential process during morphogenesis. Dissecting the signalling strategies that orchestrate EMT have shown that a complex signalling network, which controls adhesion, motility, survival and differentiation, also regulates the initiation and execution of EMT during embryonic development.
Perspectives
Timeline
The eureka enzyme: the discovery of DNA polymerase
Errol C. Friedberg
p143 | doi:10.1038/nrm1787
Opinion
Not so divided: the common basis of plant and animal cell division
Clive Lloyd & Jordi Chan
p147 | doi:10.1038/nrm1831