Table of contents
December 2006 Vol 7 No 12
From the editors
p875 | doi:10.1038/nrm2078
Research Highlights
Mitosis: BRCA1 — keeping excessive activities in check
p877 | doi:10.1038/nrm2072
DNA damage: The road of death
p878 | doi:10.1038/nrm2073
Metastasis: Contract and move
p878 | doi:10.1038/nrm2077
In the news
Of cows and men
p878 | doi:10.1038/nrm2079
In brief
Apoptosis | Development | Signal transduction | Sumoylation
p879 | doi:10.1038/nrm2075
Structure Watch
A dramatic way to remodel
p880 | doi:10.1038/nrm2064
Cell signalling: Even receptors get stressed
p880 | doi:10.1038/nrm2068
Membrane trafficking: GEF a move on!
p881 | doi:10.1038/nrm2065
Stem cells: The potential of networking
p881 | doi:10.1038/nrm2071
Development: MicroRNA knocks some sense into senseless
p882 | doi:10.1038/nrm2074
Cell polarity: Independent partners
p882 | doi:10.1038/nrm2076
Bioenergetics: Turn up the heat
p883 | doi:10.1038/nrm2070
Reviews
Adipocyte differentiation from the inside out
Evan D. Rosen and Ormond A. MacDougald
p885 | doi:10.1038/nrm2066
Adipogenesis is a complex process that involves the integration of a network of signalling pathways and transcription factors. Elucidation of this network will help us understand the events that underlie adipocyte development, with implications for the growing burden of metabolic diseases.
Powering membrane traffic in endocytosis and recycling
Thierry Soldati and Manfred Schliwa
p897 | doi:10.1038/nrm2060
Membrane-trafficking systems are spatially and temporally organized by the cytoskeleton and molecular motors. In the various endocytic and recycling transport events, microtubule-based long-range transport and actin-based short-range transport require the tightly regulated coordination of myosin, kinesin and dynein motors.
Membrane-protein topology
Gunnar von Heijne
p909 | doi:10.1038/nrm2063
The concept of membrane-protein topology is at least 30-years old. However, proteome-wide data on topology, increasing numbers of high-resolution structures and detailed studies on individual proteins are now showing us how topology is determined by the amino-acid sequence.
Editor meets silencer: crosstalk between RNA editing and RNA interference
Kazuko Nishikura
p919 | doi:10.1038/nrm2061
Adenosine to inosine (A
I) RNA editing was once thought to affect only selected transcripts by altering the proteins they encode. But, numerous AI RNA editing sites have recently been discovered in inverted repeats in non-coding regions. Also, AI RNA editing frequently interacts with RNA-interference pathways.
Replisome assembly and the direct restart of stalled replication forks
Ryan C. Heller and Kenneth J. Marians
p932 | doi:10.1038/nrm2058
The DNA-damage-induced stalling or collapse of a replication fork can cause genomic instability. This can be avoided by repair and replication-restart mechanisms, but recent evidence indicates that the removal of the blocking lesion is not always required for replication to resume.
Perspectives
Innovation
Combinatorial microscopy
Daniel Axelrod and Geneva M. Omann
p944 | doi:10.1038/nrm2062
Several new optical microscopy techniques have recently emerged that each use different combinations of photon properties. These combinatorial microscopy techniques allow the visualization of location, orientation, motion and environment of proteins and organelles well below the classic resolution limit.
Innovation
Functional and quantitative proteomics using SILAC
Matthias Mann
p952 | doi:10.1038/nrm2067
Stable-isotope labelling by amino acids in cell culture (SILAC) has emerged as a simple and powerful format for quantitative proteomics. What are the current applications for SILAC? And, how will this technology be used in the future?
Correspondence
Correspondence: The ultradian clock: not to be confused with the cell cycle
David Lloyd
| doi:10.1038/nrm1980-c1
Correspondence: The respiratory oscillation in yeast phase definitions and periodicity
Douglas B. Murray
| doi:10.1038/nrm1980-c2
Author Reply: Let the data speak
Benjamin P. Tu, Andrzej Kudlicki, Maga Rowicka and Steven L. McKnight
| doi:10.1038/nrm1980-c3
