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Review
Nature Reviews Molecular Cell Biology 7, 833–846 (1 November 2006) | doi:10.1038/nrm2039
Protein tyrosine phosphatases: from genes, to function, to disease
Abstract
The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
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