Review
Nature Reviews Molecular Cell Biology 7, 803-812 (November 2006) | doi:10.1038/nrm2042
Focus on: Systems biology: a user's guide
Collecting and organizing systematic sets of protein data
John G. Albeck1,2, Gavin MacBeath3, Forest M. White1, Peter K. Sorger1,2, Douglas A. Lauffenburger1 and Suzanne Gaudet1,2 About the authors
Abstract
Systems biology, particularly of mammalian cells, is data starved. However, technologies are now in place to obtain rich data, in a form suitable for model construction and validation, that describes the activities, states and locations of cell-signalling molecules. The key is to use several measurement technologies simultaneously and, recognizing each of their limits, to assemble a self-consistent compendium of systematic data.
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Author affiliations
- Center for Cell Decision Processes, Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
- Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
- Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Correspondence to: Douglas A. Lauffenburger1 Email: lauffen@mit.edu
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