Review
Nature Reviews Molecular Cell Biology 7, 813-819 (November 2006) | doi:10.1038/nrm2030
Linking data to models: data regression
Khuloud Jaqaman1 & Gaudenz Danuser1 About the authors
Abstract
Mathematical models are an essential tool in systems biology, linking the behaviour of a system to the interactions between its components. Parameters in empirical mathematical models must be determined using experimental data, a process called regression. Because experimental data are noisy and incomplete, diagnostics that test the structural identifiability and validity of models and the significance and determinability of their parameters are needed to ensure that the proposed models are supported by the available data.
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Author affiliations
- Department of Cell Biology, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA.
Correspondence to: Gaudenz Danuser1 Email: gdanuser@scripps.edu
Published online 27 September 2006
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