Review
Nature Reviews Molecular Cell Biology 7, 751-761 (October 2006) | doi:10.1038/nrm2022
The replication clamp-loading machine at work in the three domains of life
Chiara Indiani1 & Mike O'Donnell1 About the authors
Abstract
Sliding clamps are ring-shaped proteins that tether DNA polymerases to DNA, which enables the rapid and processive synthesis of both leading and lagging strands at the replication fork. The clamp-loading machinery must repeatedly load sliding-clamp factors onto primed sites at the replication fork. Recent structural and biochemical analyses provide unique insights into how these clamp-loading ATPase machines function to load clamps onto the DNA. Moreover, these studies highlight the evolutionary conservation of the clamp-loading process in the three domains of life.
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Author affiliations
- Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10021, USA.
Correspondence to: Mike O'Donnell1 Email: odonnel@mail.rockefeller.edu
Published online 6 September 2006
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