Abstract

The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.

Author affiliations

1. Yonatan B. Tzur and Yosef Gruenbaum are at the Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.
2. Katherine L. Wilson is at the Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, USA.

Correspondence to: Katherine L. Wilson² Email: gru@vms.huji.ac.il

Correspondence to: Yosef Gruenbaum¹ Email: klwilson@jhmi.edu

Published online 23 August 2006

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