TABLE 1 | ILK substrates
From the following article:
ILK, PINCH and parvin: the tIPP of integrin signalling
Kyle R. Legate, Eloi Montañez, Oliver Kudlacek & Reinhard Füssler
Nature Reviews Molecular Cell Biology 7, 20-31 (January 2006)
doi:10.1038/nrm1789
| Substrate | Biochemistry | Cell culture | In vivo | References |
|---|---|---|---|---|
| ILK |  | 7 | ||
 1 integrin | | 7 | ||
| 3 integrin | | 11 | ||
| AKT/PKB | | ,  * | ‡, § | 71,74–76,111 |
| GSK3 | | ,* | ‡,§ | 71,74,75,111,124 |
| Myosin light chain | | 70 | ||
| Myelin basic protein | | 7 | ||
| -parvin | | 14 | ||
| MYPT1 | | 125 | ||
 -NAC | | | 126 | |
| CPI17 | | 127,128 | ||
| PHI1 | | 127,128 | ||
| *Cell culture using Ilk-/- fibroblasts. | ||||
| ‡Ilk overexpressed in mammary epithelium. | ||||
| §Ilk-/- chondrocytes. CPI17, protein-kinase-C-dependent phosphatase inhibitor of 17 kDa; GSK3, glycogen-synthase kinase-3; ILK, integrin-linked kinase; MYPT1, myosin-light-chain-phosphatase target subunit-1; -NAC, nascent-polypeptide-associated complex and coactivator-; PHI1, phosphatase-holoenzyme inhibitor-1; PKB, protein kinase B. | ||||
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