Review
Nature Reviews Molecular Cell Biology 7, 45-53 (January 2006) | doi:10.1038/nrm1830
Subject Category: Developmental cell biology
Developmental cell biology: Making digit patterns in the vertebrate limb
Cheryll Tickle1 About the author
Abstract
The vertebrate limb has been a premier model for studying pattern formation — a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.
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Author affiliations
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Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.
Email: c.a.tickle@dundee.ac.uk
Published online 21 December 2005
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