Review
Nature Reviews Molecular Cell Biology 7, 20-31 (January 2006) | doi:10.1038/nrm1789
ILK, PINCH and parvin: the tIPP of integrin signalling
Kyle R. Legate1, Eloi Montañez1, Oliver Kudlacek1 & Reinhard Füssler1 About the authors
Abstract
The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse signalling pathways. All these proteins have synergistic functions at focal adhesions, but recent work has indicated that these proteins might also have separate roles within a cell. They function as regulators of gene transcription or cell–cell adhesion.
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Author affiliations
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Department of Molecular Medicine, Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsreid, Germany.
Email: legate@biochem.mpg.de
Email: montanez@biochem.mpg.de
Email: kudlacek@biochem.mpg.de
Email: faessler@biochem.mpg.de
Published online 21 December 2005
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