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Perspective
Nature Reviews Molecular Cell Biology 6, 743–748 (1 September 2005) | doi:10.1038/nrm1712
Two-way traffic: centrosomes and the cell cycle
Abstract
The well recognized activities of the mammalian centrosome — microtubule nucleation, duplication, and organization of the primary cilium — are under the control of the cell cycle. However, the centrosome is more than just a follower of the cell cycle; it can also be essential for the cell to transit G1 and enter S phase. How the centrosome influences G1 progression is a mystery.
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