Review
Nature Reviews Molecular Cell Biology 6, 689-701 (September 2005) | doi:10.1038/nrm1716
Article series: Developmental Cell Biology
G proteins in development
Craig C. Malbon1 About the author
Abstract
The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and various ion channels. The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development.
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Author affiliations
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Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, USA.
Email: craig@pharm.stonybrook.edu
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