Review
Nature Reviews Molecular Cell Biology 6, 702-714 (September 2005) | doi:10.1038/nrm1711
Proteomics of organelles and large cellular structures
John R. Yates III1, Annalyn Gilchrist2, Kathryn E. Howell3 & John J. M. Bergeron2 About the authors
Abstract
The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures. Traditional cell-biology techniques are used to enrich these structures for proteomics analyses, and such analyses provide insights into the biology and functions of these structures. Here, we review the state-of-the-art proteomics techniques for the analysis of subcellular structures and discuss the biological insights that have been derived from such studies.
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Author affiliations
- Department of Cell Biology, 10550 North Torrey Pines Road, The Scripps Research Institute, La Jolla, California 92037, USA.
- Department of Anatomy and Cell Biology, Strathcona Anatomy and Dentistry Building, McGill University, Montreal, Quebec H3A 2B2, Canada.
- Department of Cell and Developmental Biology, Mail Stop 8108, University of Colorado School of Medicine at Fitzsimons, P.O. BOX 6511, Aurora, Colarado 80045, USA.
Correspondence to: John R. Yates III1 Email: jyates@scripps.edu
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