Perspectives
Nature Reviews Molecular Cell Biology 6, 738-742 (September 2005) | doi:10.1038/nrm1710
Opinion: Peroxisomal matrix protein import: the transient pore model
Ralf Erdmann1 & Wolfgang Schliebs1 About the authors
Abstract
Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal translocation machinery from the well-characterized translocons of other organelles. How proteins are transported across the peroxisomal membrane is unclear. Here, we propose a mechanistic model that conceptually divides the import process into three consecutive steps: the formation of a translocation pore by the import receptor, the ubiquitylation of the import receptors, and pore disassembly/receptor recycling.
Author affiliations
- Ralf Erdmann and Wolfgang Schliebs are at the Institute for Physiological Chemistry, Faculty of Medicine, Ruhr-University Bochum, Bochum 44780, Germany.
Correspondence to: Ralf Erdmann1 Email: ralf.erdmann@rub.de
Published online 15 August 2005
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