Review
Nature Reviews Molecular Cell Biology 6, 599-609 (August 2005) | doi:10.1038/nrm1700
Ubiquitin and ubiquitin-like proteins as multifunctional signals
Rebecca L. Welchman1, Colin Gordon2 & R. John Mayer1 About the authors
Abstract
Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the activities of proteins. The central structural element of these post-translational modifications is the ubiquitin superfold. A common ancestor based on this superfold has evolved to give various proteins that are involved in diverse activities in the cell.
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Author affiliations
- School of Biomedical Sciences,University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
- MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
Correspondence to: R. John Mayer1 Email: John.Mayer@nottingham.ac.uk
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