Perspectives
Nature Reviews Molecular Cell Biology 6, 657-663 (August 2005) | doi:10.1038/nrm1697
Mitochondrial fission in apoptosis
Richard J. Youle1 & Mariusz Karbowski1 About the authors
Abstract
Mitochondria fuse and divide continuously within cells to form a dynamic network. One of the steps in apoptosis is the fragmentation of mitochondria, and recent evidence indicates that the mitochondrial fission machinery actively participates in the process of programmed cell death.
Author affiliations
- Richard J. Youle and Mariusz Karbowski are in the Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
Correspondence to: Richard J. Youle1 Email: youler@ninds.nih.gov
Published online 15 July 2005
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