Abstract

Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.

Author affiliations

1. Department of Cell and Developmental Biology, University of Colorado School of Medicine, 12801 East 17th Avenue, Box 8018, Aurora, Colorado 80045, USA.
   Email: joan.hooper@uchsc.edu
2. Departments of Developmental Biology, Genetics and Bioengineering, Howard Hughes Medical Institute, Clark Center W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, California 94305-5439, USA.
   Email: scott@cmgm.stanford.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.