Review
Nature Reviews Molecular Cell Biology 6, 298-305 (April 2005) | doi:10.1038/nrm1616
Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone1 & Leonard Guarente1 About the authors
Abstract
Calorie restriction (CR) is the only experimental manipulation that is known to extend the lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non-human primates. In addition, CR has been shown to reduce the incidence of age-related disorders (for example, diabetes, cancer and cardiovascular disorders) in mammals. The mechanisms through which this occurs have been unclear. CR induces metabolic changes, improves insulin sensitivity and alters neuroendocrine function in animals. In this review, we summarize recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing.
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Author affiliations
- Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Correspondence to: Leonard Guarente1 Email: leng@mit.edu
Published online 15 March 2005
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