Review
Nature Reviews Molecular Cell Biology 6, 827-837 (November 2005) | doi:10.1038/nrm1743
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
Walter Kolch1,2 About the author
Abstract
The pathway from Ras through Raf and MEK (MAPK and ERK kinase) to ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) regulates many fundamental cellular processes. Recently, a number of scaffolding proteins and endogenous inhibitors have been identified, and their important roles in regulating signalling through this pathway are now emerging. Some scaffolds augment the signal flux, but also mediate crosstalk with other pathways; certain adaptors target MEK–ERK/MAPK complexes to subcellular localizations; others provide regulated inhibition. Computational modelling indicates that, together, these modulators can determine the dynamic biological behaviour of the pathway.
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Author affiliations
- Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
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Institute of Biomedical and Life Sciences, Sir Henry Wellcome Functional Genomics Facility, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ, UK.
Email: wkolch@beatson.gla.ac.uk
Published online 14 October 2005
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