Review
Nature Reviews Molecular Cell Biology 6, 56-68 (January 2005) | doi:10.1038/nrm1549
Focal adhesion kinase: in command and control of cell motility
Satyajit K. Mitra1, Daniel A. Hanson1 & David D. Schlaepfer1 About the authors
Abstract
A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
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Author affiliations
- The Scripps Research Institute, Department of Immunology, IMM21 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Correspondence to: David D. Schlaepfer1 Email: dschlaep@scripps.edu
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